A versatile method for the synthesis of 3-alkoxycarbonyl beta-lactam derivatives |
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| Authors: | Jiao Lei Zhang Qianfeng Liang Yong Zhang Shiwei Xu Jiaxi |
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| Institution: | Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China. |
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| Abstract: | reaction: see text] Ketene-imine cycloaddition reactions (the Staudinger reaction) of ethoxycarbonyl(phenylthio)ketene with various imines and subsequent desulfurization reactions were employed to synthesize 3-ethoxycarbonyl beta-lactam derivatives. The results indicate that the current approach provides a convenient, mild, and versatile method for synthesizing a variety of 3-alkoxycarbonyl trans-beta-lactam derivatives with good to excellent yields and diastereoselectivities. |
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