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Synthesis of 1,2,3-triazole moiety-containing NAD analogs and their potential as redox cofactors |
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| Authors: | Shuhua Hou Wujun LiuDebin Ji Qian WangZongbao Kent Zhao |
| Institution: | a Dalian Institute of Chemical Physics, CAS, Dalian 116023, PR China b Graduate University of Chinese Academy of Sciences, Beijing 100039, PR China c Dalian National Laboratory for Clean Energy, Dalian 116023, PR China |
| Abstract: | Thirteen 1,2,3-triazole moiety-containing NAD analogs were synthesized and evaluated as redox cofactors. Noticeable enzymatic activities were observed when these analogs were employed as cofactors for malic enzyme or alcohol dehydrogenase. Our results indicated that the natural NAD-dependent oxidoreductases possessed flexible NAD binding pockets. |
| Keywords: | NAD analogs Malic enzyme Alcohol dehydrogenase Promiscuity |
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