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Lignan glucoside from Sinopodophyllum emodi and its cytotoxic activity |
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| Authors: | Chang Qi Zhao Yan Yan Zhua Shu Ying Chenb Yukio Ogiharac a Beijing Key Lab of Gene Engineering Drugs & Biological Technology Key Lab for Cell Proliferation & Regulation Biology of Ministry of Education College of Life Sciences Beijing Normal University Beijing China b Faculty of Agronome Biotechnology Yunnan Agriculture University Kunming China c Faculty of Pharmaceutical Sciences Nagoya City University Nagoya - Japan |
| Affiliation: | a Beijing Key Lab of Gene Engineering Drugs & Biological Technology, Key Lab for Cell Proliferation & Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China;b Faculty of Agronome and Biotechnology, Yunnan Agriculture University, Kunming 650201, China;c Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan |
| Abstract: | A new lignan glycoside was isolated from the n-butanol extract of the roots and rhizomes of Sinopodophyllum emodi. On the basis of spectral evidences, its structure was established and named as 4, 5-didemethylpodophyllotoxin 7'-O-β-D- glucopyranoside. This compound showed cytotoxicity against four human cancer cell lines (Hela, K562, SH-SY5Y and CNE) in vitro. |
| Keywords: | Sinopodophyllum emodi Berberidaceae 4, 5-Didemethylpodophyllotoxin 7&prime -O-&beta -D-Glucopyranoside Cytotoxicity |
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