Relationship between wavelength combination and signal-to-noise ratio in measuring hemoglobin concentrations using visible or near-infrared light |
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Authors: | Tsukasa Funane Hirokazu Atsumori Hiroki Sato Masashi Kiguchi Atsushi Maki |
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Institution: | (1) Advanced Research Laboratory, Hitachi, Ltd., Hatoyama, Saitama 350-0395, Japan |
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Abstract: | The signal-to-noise ratio (SNR), when using visible or near-infrared light to measure the change in hemoglobin concentration
length (the product of hemoglobin concentration and optical path length in this study), depends on the wavelength combination
and the analysis method. Although the SNRs increase when detected or incident optical power increases, the optical power should
be limited because of safety standards. Considering these safety standards, we assumed that the total optical power was constant
by using the relationship between optical power and measurement error. We investigated the theoretical estimation errors of
the changes in hemoglobin concentration length using two, three, and four different wavelengths. The SNRs of the changes in
hemoglobin concentration length were high when fewer wavelengths were used. These SNRs decreased when the redox state change
in cytochrome oxidase was included in the analysis. |
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Keywords: | optical topography wavelength combination signal-to-noise ratio hemoglobin concentration near-infrared light cytochrome oxidase laser safety standards |
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