大麻二酚纳米结构脂质载体的制备及其性质研究

通过高压均质法制备包载大麻二酚(CBD)的纳米结构脂质载体(CBD-NLC),并考察其载药量、包封率、平均粒径、Zeta电位、长期储存稳定性等物理化学性质，筛选获得CBD-NLC最佳配方。在优化条件下制备的CBD-NLC平均粒径为163.7±1.3nm,多分散性指数(PDI)为0.14±0.02,包封率和载药量分别为95.5±1.0%和9.8±0.1%。通过透射电镜、傅里叶变换红外光谱、差示量热扫描、X射线衍射对CBD-NLC进行表征，结果表明，CBD被很好地负载在NLC中，CBD-NLC主要为球形结构。与文献报道相比，纳米结构脂质载体能够包载CBD,具有较好的载药量和包封率，可解决CBD的溶解性及稳定性问题，提高CBD的有效利用度。制备的CBD-NLC可用去离子水以任意比例稀释，具有良好的稳定性，便于其在医药产品中的应用。

Preparation and characterization of cannabidiol loaded nanostructured lipid carrier

The nanostructured lipid carrier containing cannabidiol (CBD-NLC) was prepared by the high-pressure homogenization method, and its drug loading, encapsulation efficiency, average particle size, zeta potential, long-term storage stability and other physical-chemistry properties were investigated to obtain the best formula of CBD-NLC. The average particle size of CBD-NLC prepared under the optimized conditions was 163.7±1.3nm, the polydispersity index (PDI) was 0.14±0.02, the encapsulation efficiency and drug loading were 95.5±1.0% and 9.8±0.1%, respectively. Physical chemical properties of CBD-NLC were characterized by the experiments of transmission electron microscope, fourier transform infrared spectrometer, differential scanning calorimeter and X-ray diffractometer. The results showed that CBD was well loaded in NLC, and most CBD-NLC particles have the spherical shape. Compared with literature reports, the nanostructured lipid carrier can encapsulate cannabidiol with better drug loading and encapsulation efficiency, which can solve the solubility and stability problems of CBD, and improve the effective utilization of CBD. The CBD-NLC has good stability, which can be diluted with deionized water in any proportion, and is convenient for its application in pharmaceutical products.