Identification of characteristic protein folding channels in a coarse-grained hydrophobic-polar peptide model |
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Authors: | Schnabel Stefan Bachmann Michael Janke Wolfhard |
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Institution: | Institut für Theoretische Physik, Universit?t Leipzig, Augustusplatz 10/11, D-04109 Leipzig, Germany. |
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Abstract: | Folding channels and free-energy landscapes of hydrophobic-polar heteropolymers are discussed on the basis of a minimalistic off-lattice coarse-grained model. We investigate how rearrangements of hydrophobic and polar monomers in a heteropolymer sequence lead to completely different folding behaviors. Studying three exemplified sequences with the same content of hydrophobic and polar residues, we can reproduce within this simple model two-state folding, folding through intermediates, as well as metastability. |
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