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A lanthanide nanoparticle-based luminescent probe for folic acid |
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| Authors: | Forugh Gudarzy Abdolmajid Bayandori Moghaddam Shahla Mozaffari Yadolah Ganjkhanlou Mahmood Kazemzad Reza Zahed Farhad Bani |
| Affiliation: | 1. Department of Chemistry, Payame Noor University, P.O. Box 19395-3697, Tehran, Iran 2. Department of Engineering Science, College of Engineering, University of Tehran, P.O. Box 11155-4563, Tehran, Iran 3. Materials and Energy Research Center, P.O. Box 14155-4777, Tehran, Iran 4. Department of Emergency Medicine, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran 5. Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran |
| Abstract: | We report on a novel luminescent method for the detection of folic acid (FA), a member of the vitamin B family. Y2O3 nanoparticles were doped with europium(III) ions and surface-modified with captopril. Their fluorescence is quenched by FA, and intensity is a function of folic acid concentration in the 0.1 – 40 μM concentration range. The detection limit is 83 nM of FA at pH 7 and room temperature. In this work, we propose a novel method based on the changes in the fluorescence intensity of nanoparticles. Modified Eu-doped Y2O3 nanoparticles by captopril have been used as a probe for the detection of folic acid. |
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