Mechanisms of 5'-O-Benzoyl-2,3'-anhydrothymidine Reactions with Nucleophiles: II. Kinetics of the Reaction with Triethylammonium Tetrazolide in DMF |
| |
Authors: | A A Malin E V Korchevskaya M B Shcherbinin V A Ostrovskii |
| |
Institution: | (1) St. Petersburg Technological Institute, Moskovskii pr. 26, St. Petersburg, 198013, Russia |
| |
Abstract: | The reaction of 5'-O-benzoyl-2,3'-anhydrothymidine with triethylammonium tetrazolide in DMF at 100-120°C is described by a second-order kinetic equation, following the first-order kinetics in each of the reactants. On the basis of the experimental activatin parameters, H 298 = 80 kJ/mol, S = -116 J× mol-
1 K-
1, a mechanism was proposed, according to which in the rate-determining stage of SN2 reaction triethylammonium tetrazolide attacks the C3
' atom of 5'-O-benzoyl-2,3'-anhydrothymidine with simultaneous loosening of the C3
'ÄO2 anhydro bond. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|