|
|||||
|
|
In vivo lactate editing in single voxel proton spectroscopy and proton spectroscopic imaging by homonuclear polarisation transfer |
|
| Institution: | 1. The Computational, Cognitive and Clinical Neuroimaging Laboratory, Division of Brain Sciences, Imperial College London, London W12 0NN, UK;2. Department of Bioengineering, Imperial College London, London SW7 2AZ, UK;3. Department of Mathematics, Imperial College London, London SW7 2AZ, UK;4. Department of Biomedical Engineering, King''s College London, London SE1 7EH, UK;1. Centre for Medical Image Computing (CMIC), Computer Science Department, University College London, United Kingdom;2. Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom;3. School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom;4. Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal;5. AINOSTICS Ltd., Manchester, United Kingdom;6. NatBrainLab, Institute of Psychiatry, Psychology and Neuroscience, King''s College London, London, United Kingdom |
| Abstract: | Volume-selective lactate editing has been performed successfully in vitro and in vivo in the brain on a clinical scanner using a PRESS-based single voxel 1H spectroscopy and a 1H spectroscopic imaging sequence. The PRESS sequence was made sensitive to homonuclear polarisation by replacing the standard 180° refocusing pulses with 90° pulses. Two acquisitions were made at a total echo time around 2/J (J is the coupling constant for CH and CH3 spins in lactate ≈7 Hz) whose individual echo times differed by 5.5 ms. Subtraction of one signal from the other yielded the lactate resonance alone. The technique is an effective method of separating the overlapping signals of lactate and lipids. Furthermore this editing method can be performed without state of the art MRI scanner hardware. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |