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Peroxide-Containing Chitosan Derivative for Hydrogel Synthesis |
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| Authors: | Nadiya Solomko Olga Budishevska Andriy Voronov Ananiy Kohut Andriy Popadyuk Stanislav Voronov |
| Institution: | 1. Lviv National Polytechnic University, Bandera str. 12, 79013, Lviv, Ukraine;2. Department of Coatings and Polymers Materials, Dep.2760, North Dakota State University, Fargo, 58108, ND, USA |
| Abstract: | Summary: Peroxide-containing chitosan was synthesized using a polymer-analogous reaction between chitosan and tert-butylperoxymethyl ester of maleic acid. Peroxide-containing chitosan macromolecules cross-link into a polymeric hydrogel network in the presence of 1-vinyl-2-pyrrolidone upon heating. Polymeric hydrogels are formed due to reactions of radical chain transfer and recombination. Reacting radical species are chitosan macroradicals and poly(vinylpyrrolidone) macroradicals formed by decomposition of peroxide-containing fragments. Synthesized hydrogels are pH-responsive and facilitate drug release. |
| Keywords: | drug release by hydrogels peroxide-containing chitosan pH-responsive hydrogels |