Calibration of a polychromatic CT equipment for biological tissue samples enriched with magnetic nanoparticles.

Micro-computed tomography (µCT) is a widely used imaging technique. Tomography has been used to study the distribution of magnetic nanoparticles within cancerous tissue after minimal-invasive cancer treatments such as magnetic drug targeting and magnetic hyperthermia. But not only the distribution is a relevant factor for the sucess of these therapeutic aproaches. The concentration of the magnetic nanoparticles within the respective tissue is also of great impact. In this paper we present a calibration procedure of a µCT-equipment for biological tissue samples enriched with magnetic nanoparticles developed to enable a semi-quantitative evaluation of 3-dimensional data sets. (© 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)