A Microscopic model for a cell-seeded material |
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| Authors: | Jeong Hun Yi Marcus Stoffel Dieter Weichert Karsten Gavenis Ralf Müller-Rath |
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| Affiliation: | 1. Institut für Allgemeine Mechanik, RWTH Aachen;2. Klinik für Orthopädie und Unfallchirurgie, Uniklinik Aachen |
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| Abstract: | The aim of the present paper is to account for the growth of fiber which is observed in a cell-seeded material stimulated in a bioreactor. For this purpose, the change of mass is considered in the balance laws, and the deformation energy is assumed to be a function of varying mass and the Helmholtz free-energy. Fiber growth at the microscopic level causes a macroscopic change of the material's mechanical properties. The study is a first approach towards a micromechanical model accounting for remodelling in cartilage replacement materials. In so doing, constitutive equations for renewable soft tissues are proposed. (© 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim) |
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