| DNA SYNTHESIS INHIBITION OF NITROXIDE RADICALS ON LEUKEMIA CELLS |
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| 作者姓名： | 刘力生 郑荣梁 HAROLD M. SWARTZ 张自义 魏陆林 |
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| 作者单位： | Department of Biology，Lanzhou University，Department of Biology，Lanzhou University，Department of Medicine and Biophysics，University of Illinois，Department of Chemistry，Lanzhou University，Department of Chemistry，Lanzhou University |
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| 基金项目： | Project supported by the National Natural Science Foundation of China. |
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| 摘 要： | 4-isothiocyanate-2,2,6,6-tetramethyl-piperidine-l-oxyl has the strongest effects on the DNA synthesis and viability of isolated leukemia 7712 cells. This compound is a very potent inhibitor of DNA synthesis with 50% inhibition of cell DNA synthesis occurring at 2.2 μg/ml, while the LD50 for white mice is 277 mg/kg. During the concentration of 50 μg/ml, the inhibition of DNA synthesis is 99.7%, which is unable to damage the DNA replicate templet. The inhibition of this compound, a combination of nitroxide and isothiocyanate, appears to be stronger than that of the sum of the two separate actions. Much more moderate effects are seen for all the other nitroxide radicals. After reducing nitroxide to hydroxyla-mine, there is no inhibition for DNA synthesis. The free radical mechanism of carcinogene-sis and antitumor action has been discussed.
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DNA SYNTHESIS INHIBITION OF NITROXIDE RADICALS ON LEUKEMIA CELLS |
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| LIU LI-SHENG ZHENG RONG-LIANG.DNA SYNTHESIS INHIBITION OF NITROXIDE RADICALS ON LEUKEMIA CELLS[J].Science in China(Chemistry),1991(9). |
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| Authors: | LIU LI-SHENG ZHENG RONG-LIANG |
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| Abstract: | |
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| Keywords: | nitroxide radical antitumor |
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