Synthesis and stability of sulfur-35 labelled 4-ethylbicyclothiophosphate |
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| Authors: | S E Tkachenko T P Trofimova V M Fedoseev |
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| Institution: | (1) Pacific Northwest National Laboratory, 902 Battelle Blvd, P.O. Box 999, MSIN P7-02, Richland, WA 99352, USA;(2) Univeristy of Missouri Research Reactor, Columbia, MO 65211, USA;(3) Department of Chemistry, University of Missouri, Columbia, MO 65211, USA;(4) Department of Electrical and Computer Engineering, University of Missouri, Columbia, MO 65211, USA |
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| Abstract: | Different synthetic routes to the preparation of 4-ethyl-2,6,7-trioxa-1-phosphabicyclo2,2,2]octane-1-thioxide labelled with sulfur-35 have been investigated since it is of considerable interest as radioligand for neurochemistry. The thiophosphate was successfully synthesized by sulfuration of the corresponding bicyclophosphite by elemental sulfur-35, however the radiochemical purity of the material obtained in this way proves to be low. Convenient methods for synthesis of the thioxide from 35S] thiourea, based on the results of the autoradiolysis of the starting 35S] thiourea, has been discovered giving rise to thioxide with high radiochemical purity. The autoradiolytic stability of the labelled thiophosphate has been studied.M. V. Lomonosov Moscow State University, Moscow 119899, Russia Translated from Khimiya Geterotsiklicheskikh Soedinenii, No 8, pp. 1107–1111, August, 1999. |
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