One-pot preparation of fluorinated propargylamines under microwave irradiation and solvent-free conditions |
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| Authors: | Wei-Qiong Du Ran Wu Shi-Zheng Zhu |
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| Institution: | a Department of Chemistry, School of Science, Shanghai University, Shanghai, China
b Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 354 Fenglin Lu, Shanghai 200032, China |
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| Abstract: | A facile one-pot method has been developed for the synthesis of fluorine-containing propargylamines by a three-component coupling of fluorinated aldehydes, amines, and alkynes, in the presence of copper (I) chloride under microwave irradiation and solvent-free condition. This process is an efficient alternative to traditional thermal reaction. All new compounds are fully characterized by spectral methods. |
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| Keywords: | Fluorinated propargylamines Microwave Solvent free One-pot reaction Three-component coupling |
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