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CF3-substituted 1,3-dicarbonyl compounds in the Biginelli reaction promoted by chlorotrimethylsilane |
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| Authors: | Sergey V. Ryabukhin Andrey S. Plaskon Eugeniy N. Ostapchuk Oleg V. Shishkin |
| Affiliation: | a “Enamine Ltd.”, 23 A. Matrosova Street, 01103 Kyiv, Ukraine b National Taras Shevchenko University, 62 Volodymyrska Street, 01033 Kyiv, Ukraine c Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska, 02094 Kyiv, Ukraine d Institute for Scintillation Materials, National Academy of Science of Ukraine, 60 Lenina Avenue, 61001 Kharkiv, Ukraine |
| Abstract: | Trifluoromethyl-1,3-diones were investigated as reactants in the Biginelli reaction promoted by Me3SiCl. The dependence of the reaction pathway on the nature of substituent at the α-position to the carbonyl group was established. A set of new CF3-containing dihydropyrimidine(thi)one derivatives was obtained. A number of novel 5-CF3CO dihydropyrimidine(thi)ones were synthesized. |
| Keywords: | Biginelli reaction Ureas Thioureas Chlorotrimethylsilane 4-Trifluorometyl-1,3-diones |
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