Voltammetric oxidation of pharmaceutical organic compounds at a new modified electrode: The aluminum graphite spray-covered electrode |
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| Authors: | J. -M. Kauffmann, A. Laudet, J. -C. Vir , G. J. Patriarche,G. D. Christian |
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| Affiliation: | 1. Institut de Pharmacie, Université Libre de Bruxelles, Campus Plaine 205/6, Boulevard du Triomphe, B-1050 Brussels, Belgium;1. Department of Chemistry, University of Washington, Seattle, Washington 98195 USA |
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| Abstract: | A new graphite spray-modified aluminum electrode has been used to determine clozapine, clothiapine, and loxapine in acetate buffer at pH 4.7 and 20% methanol, down to 5 × 10−6 M concentrations using differential pulse voltammetry. Reproducibility exceeds that of other solid electrodes, being in the range of 1 to 2%. The electrochemical oxidation products of the latter two compounds are strongly adsorbed, causing diminished electrode response, but response is readily restored by polishing of the sprayed electrode. |
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| Keywords: | To whom all correspondence should be addressed. |
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