Short and long term stability of the elemental composition of human body fluid reference materials and their use as master lots |
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Authors: | Kari Dahl Astrid Hald Poul J?rgensen Ivar Martinsen Yngvar Thomassen |
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Affiliation: | (1) National Institute of Occupational Health, P. O. Box 8149 Dep, N-0033 Oslo 1, Norway;(2) Odense Hospital, DK-5000 Odense C, Denmark;(3) Nordic Analytical Centre Ltd, P. O. Box 47 Grorud, N-0917 Oslo 9, Norway |
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Abstract: | Summary Studies have been made of both short and long term stability of trace elements in lyophilized human body fluid reference materials, as well as the stability of mercury in reconstituted urine solutions. No detectable concentration changes for mercury, lead and aluminium occurred during the 5-year period. There are large differences in the amounts of mercury loss among different reconstituted materials. Addition of traces of gold to the solutions minimized the mercury loss and increased the useable time of the reconstituted material from hours to 8 days. A certification process based on direct determinations by reference laboratories and by comparison against master lots of the same material and against similar certified reference materials is presented. Values for calcium, copper and mercury obtained from reference laboratories and using the data transfer principle have been assigned in new batches of urine and serum. |
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