The reverse of polymer degradation: in situ crosslinked gel formation through disulfide cleavage |
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| Authors: | Saeed Aram O Newland Ben Pandit Abhay Wang Wenxin |
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| Affiliation: | Network of Excellence for Functional Biomaterials, National University of Ireland Galway, IDA Business Park, Galway, Ireland. |
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| Abstract: | In contrast to the usual inclusion of disulfide bonds within a polymer structure to facilitate bio-degradation, we have designed a self-curing "one pot" hyperbranched polymer capable of forming crosslinked gels under reducing conditions abundant in tumoural tissue. |
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