Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy |
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| Authors: | Lai Chian-Hui Lin Yu-Chuan Chou Fong-In Liang Chien-Fu Lin En-Wei Chuang Yung-Jen Lin Chun-Cheng |
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| Affiliation: | Department of Chemistry, National Tsing Hua University, 101, Sec. 2, Kuang Fu Rd., Hsinchu 30013, Taiwan. |
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| Abstract: | A multivalent galactosyl carborane derivative 10 (dendritic glyco-borane, DGB) was synthesized and demonstrated as a potential cell-targeting agent in BNCT with HepG2 cells. DGB 10 improved the delivery of boron to HepG2 cells and neutron irradiation data show DGB 10 with ten-fold improvement at killing the HepG2 cells over BSH. |
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