Limited slowdown of endocrine-disruptor diffusion in confined fluid lipid membranes |
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Authors: | Okamura Emiko Wakai Chihiro Matubayasi Nobuyuki Sugiura Yukio Nakahara Masaru |
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Institution: | Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan. emiko@scl.kyoto-u.ac.jp |
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Abstract: | Self-diffusion rates of lipids and trapped bisphenol A (BPA) are determined in various sizes of confined but fluid membranes by high-field-gradient NMR at 600 MHz. Micelles and vesicles of 3- to 400-nm diameters are used as model membranes to get an insight into the molecular diffusion in such soft environments. The slowdown of BPA and lipid motions is leveled off in 100- and 400-nm vesicles, although the hydrodynamic continuum model gives the aggregate motion slowed inversely to the aggregate size. Instead, the limited motion is related to the intra-membrane fluidity. |
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