Bubble nucleation and cooperativity in DNA melting |
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| Authors: | Ares S Voulgarakis N K Rasmussen K O Bishop A R |
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| Affiliation: | Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA. |
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| Abstract: | The onset of intermediate states (denaturation bubbles) and their role during the melting transition of DNA are studied using the Peyrard-Bishop-Dauxois model by Monte Carlo simulations with no adjustable parameters. Comparison is made with previously published experimental results finding excellent agreement. Melting curves, critical DNA segment length for stability of bubbles, and the possibility of a two-state transition are studied. |
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