1-Bromo-1-chloro-2,2,2-trifluoroethane (Halothane) as a building block for fluorine compounds |
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| Authors: | Wojciech Dmowski |
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| Affiliation: | Institute of Organic Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland |
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| Abstract: | This review provides an overview of several synthetic applications of the first fluorinated anaestetic, 1-bromo-1-chloro-2,2,2-trifluoroethane, leading to convenient preparation of numerous fluorine, and particularly, CF3 group containing compounds via organometallic (Mg, Zn) and free radical “sulphinatodehalogenation” reactions. |
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| Keywords: | 1-Bromo-1-chloro-2,2,2-trifluoroethane Halothane Fluorine compounds Trifluoromethyl compounds Grignard reactions Organozinc reactions Fluorocarbanions Radical additions Sulphinatodehalogenation Fluoroalcohols Fluoroalkenes |
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