Chiral bifunctional thiourea-catalyzed enantioselective aldol reaction of trifluoroacetaldehyde hemiacetal with aromatic ketones |
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Authors: | Jing Nie Dong-Hua Zheng Shumin Cui |
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Affiliation: | a Department of Chemistry, Tianjin University, Tianjin 300072, China b Department of Chemistry, Henan Agricultural University, Zhengzhou 450002, China |
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Abstract: | In the presence of saccharide-derived bifunctional amine-thiourea catalysts, the direct aldol condensation of trifluoroacetaldehyde methyl hemiacetal with aromatic ketones proceeds to produce (R)-β-hydroxy β-trifluoroalkyl ketones in low to moderate yields with good enantioselectivities. |
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Keywords: | Bifunctional organocatalyst Saccharide Thiourea Aldol Trifluoroacetaldehyde |
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