A Straightforward Approach to Tetrahydroindolo[3,2‐b]carbazoles and 1‐Indolyltetrahydrocarbazoles through [3+3] Cyclodimerization of Indole‐Derived Cyclopropanes |
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| Authors: | Dr Olga A Ivanova Dr Ekaterina M Budynina Prof Victor N Khrustalev Dr Dmitriy A Skvortsov Dr Igor V Trushkov Prof Mikhail Ya Melnikov |
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| Institution: | 1. Department of Chemistry, M. V. Lomonosov Moscow State University, Moscow, (Russian Federation);2. Laboratory of Chemical Synthesis, Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, (Russian Federation);3. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, (Russian Federation);4. Peoples' Friendship University of Russia, Moscow, (Russian Federation) |
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| Abstract: | A rapid new approach to produce biologically relevant bisindoles, namely indolyltetrahydrocarbazoles and indolo3,2‐b]carbazoles, has been developed, based on the Ga(OTf)3‐catalyzed 3+3] cyclodimerization of indole‐derived donor–acceptor cyclopropanes. Chemoselectivity of the process depends on the location of the three‐membered ring at the indole core. |
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| Keywords: | cyclopropanes dimerization domino reactions indoles Lewis acids |
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