Sandmeyer‐Type Trifluoromethylthiolation and Trifluoromethylselenolation of (Hetero)Aromatic Amines Catalyzed by Copper |
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Authors: | Christian Matheis Victoria Wagner Prof. Dr. Lukas J. Goossen |
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Affiliation: | FB Chemie‐Organische Chemie, Technische Universit?t Kaiserslautern, Erwin‐Schr?dinger‐Strasse, Geb.?54, 67663 Kaiserslautern (Germany) http://www.chemie.uni‐kl.de/goossen |
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Abstract: | Aromatic and heteroaromatic diazonium salts were efficiently converted into the corresponding trifluoromethylthio‐ or selenoethers by reaction with Me4NSCF3 or Me4NSeCF3, respectively, in the presence of catalytic amounts of copper thiocyanate. These Sandmeyer‐type reactions proceed within one hour at room temperature, are applicable to a wide range of functionalized molecules, and can optionally be combined with the diazotizations into one‐pot protocols. |
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Keywords: | copper fluorine fluoroalkylthiolation Sandmeyer reaction synthetic methods |
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