Study of the base-catalysed oxidation of the anti-bacterial and anti-protozoal agent metronidazole by permanganate ion in alkaline medium |
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| Authors: | Aftab Aslam Parwaz Khan Anish Khan Abdullah M Asiri Naved Azum Malik Abdul Rub Sher Bahadar Khan Mohammed M Rahman Abdulrahman O Al-Youbi |
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| Institution: | 1. Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah, 21589, Saudi Arabia
2. Center of Excellence for Advanced Materials Research, King Abdulaziz University, P.O. Box 80203, Jeddah, 21589, Saudi Arabia
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| Abstract: | The mechanism of dismutation of MnO4 2? via the complex MTZ–MnO4·OH]2?, formed during the oxidation of metronidazole (MTZ), has been investigated spectrophotometrically at different temperatures. The stoichiometry of the reaction is 1:1, i.e. 1 mol MTZ reacts with 1 mol Mn(VII).The reaction is first order in permanganate, less than first order in MTZ] and alkali]. The effects of added products and the dielectric constant and ionic strength of the reaction medium were investigated. The main products were identified by spot test and FT-IR. A mechanism involving a free radical has been proposed. In the equilibrium step MTZ binds to the MnO4 ? species to form a complex (C). Investigation of the reaction at different temperatures enabled determination of the activation data for the slow step of proposed mechanism. The proposed mechanism and the derived rate laws are consistent with the observed kinetics. |
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