Distribution of samarium and ytterbium in rats measured by enriched stable isotope tracer technique and INAA |
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Authors: | Fuliang Li Yuqi Wang Zhiyong Zhang Jingxin Sun Haiqing Xiao Zhifang Chai |
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Affiliation: | (1) Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, P.O. Box 2732, Beijing, 100080, P.R. China |
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Abstract: | In the present study a method using enriched stable isotope tracer and instrumental neutron activation analysis (INAA) was developed to study the dynamic distribution of rare earth elements (REEs) in a variety of organs and tissues of Wistar rats. Stable isotopes 152Sm and 168Yb were selected as tracers for the experiment. Intravenously injected 152Sm and 168Yb in chloride form could be quickly absorbed and distributed in almost all the organs and tissues of interest, including liver, skeleton, kidney, spleen, heart, lung, testicle, and blood serum. Liver and skeleton had high ability to take up 152Sm and 168Yb under the experimental conditions, whereas the contents of the elements in other organs were generally lower than 2% of the given dose during the whole experimental period. The difference in distribution of 152Sm and 168Yb in the body was also discussed. |
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