Preparation,Characterization of Hydrophobic Drug in Combine Loaded Chitosan/Cyclodextrin/Trisodium Citrate Nanoparticles and in vitro Release Study |
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Authors: | JI Jin-gou ZHANG Jing-fen HAO Shi-lei WU Dan-jun LIU Li XU Yi |
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Institution: | College of Chemistry and Chemical Engineering, University of Chongqing, Chongqing 400030, P. R. China |
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Abstract: | Chitosan/cyclodextrin/trisodium citrate(CS/CD/TSC) nanoparticles with ibuprofen(IBU) loaded were prepared via the ionic cross-linking method, with trisodium citrate selected as the cross-linking agent. The drug-loading capacity, particle size, zeta potential and surface morphology of the obtained nanoparticles were investigated. The results show a good drug-loading capacity. The prepared nanoparticles were spherical in shape with an average size of 293.7 nm and a zeta potential of +30.72 mV. The in vitro release studies show that the controlled release of IBU from the nanoparticles was followed. The drug release from CS/β-CD/TSC nanoparticles followed non-Fickian or anomalous diffusion. |
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Keywords: | Chitosan Cyclodextrin Nanoparticle Ibuprofen(IBU) |
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