| Synthesis of Obyanamide, a Marine Cytotoxic Cyclic Depsipeptide |
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| 引用本文： | Wei ZHANG Ni SONG Zhong Zhen LI Ying Xia LI. Synthesis of Obyanamide, a Marine Cytotoxic Cyclic Depsipeptide[J]. 中国化学快报, 2006, 17(3): 285-288 |
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| 作者姓名： | Wei ZHANG Ni SONG Zhong Zhen LI Ying Xia LI |
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| 作者单位： | Wei ZHANG，Ni SONG，Zhong Zhen LI，Ying Xia LI* Key Laboratory of Marine Drugs，the Ministry of Education of China，Marine Drug and Food Institute，Ocean University of China，Qingdao 266003 |
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| 基金项目： | This work was financially supported by the National Natural Science Foundation of China （30572245）. |
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| 摘 要： | Obyanamide 1 is a cyclic depsipeptide that was recently isolated from the marine cyanobacterium Lyngbya confervoides by Moore and co-workers1. This compound displayed a potent inhibitory effect on both KB and LoVo cells in vitro. Several structural analog…
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| 关 键 词： | 合成 海洋天然化合物 分离 N-甲基-α-氨基酸 β-氨基酸 结构活性 天然环酯肽 丝状鞘丝藻 抗肿瘤药物 |
| 收稿时间： | 2005-08-26 |
Synthesis of Obyanamide, a Marine Cytotoxic Cyclic Depsipeptide |
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| Wei ZHANG,Ni SONG,Zhong Zhen LI,Ying Xia LI. Synthesis of Obyanamide, a Marine Cytotoxic Cyclic Depsipeptide[J]. Chinese Chemical Letters, 2006, 17(3): 285-288 |
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| Authors: | Wei ZHANG Ni SONG Zhong Zhen LI Ying Xia LI |
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| Abstract: | The synthesis of a marine cytotoxic cyclic depsipeptide obyanamide has been accomplished. The key steps include assembling liner pentapeptide via Yamaguchi esterification and HATU-promoted ring closing. The structure of the synthetic sample was identified by 1H and 13C NMR, H-H COSY, HMQC, HMBC, and HRESIMS, but appears to be different from that of the marine natural product. |
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| Keywords: | Obyanamide synthesis cyclic depsipeptide natural product. |
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