Design,synthesis, and insecticidal bioactivities evaluation of pyrrole- and dihydropyrrole-fused neonicotinoid analogs containing chlorothiazole ring |
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| Authors: | Hong-Feng Shen Xi Chen Pin Liao Xu-Shen Shao Zhong Li Xiao-Yong Xu |
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| Institution: | a Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China;
b Shanghai Collaborative Innovation Center for Biomanufacturing Technology, Shanghai 200237, China |
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| Abstract: | Chlorothiazole ring, as a substituted heterocycle, frequently occurred in structures of various insecticides, and brought positive effect on bioactivity. In purpose to find novel neonicotinoids, a series of pyrrole- and dihydropyrrole-fused neonicotinoid analogs containing chlorothiazole ring were synthesized for the first time. Results of the following biological assays showed that compounds 5a-c achieved good insecticidal activity against Aphis craccivora, and compound 5h exhibited good activity against Nilaparvata lugens. |
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| Keywords: | Neonicotinoid Pyrrole Dihydropyrrole Insecticidal activity |
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