| Cu(Ⅱ)-catalyzed domino reaction of 2-halobenzamide and arylmethanamine to construct 2-aryl quinazolinone |
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| 引用本文： | Ben-Quan Hu,Li-Xia Wang,Jun-Feng Xiang,Luo Yang,Ya-Lin Tang. Cu(Ⅱ)-catalyzed domino reaction of 2-halobenzamide and arylmethanamine to construct 2-aryl quinazolinone[J]. 中国化学快报, 2015, 26(3): 369-372. DOI: 10.1016/j.cclet.2014.12.006 |
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| 作者姓名： | Ben-Quan Hu Li-Xia Wang Jun-Feng Xiang Luo Yang Ya-Lin Tang |
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| 作者单位： | a State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing 100190, China;b Key Laboratory for Environmentally Friendly Chemistry and Application, Department of Chemistry, Xiangtan University, Hunan 411105, China |
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| 基金项目： | The authors wish to thank the National Natural Science Foundation of China (Nos. 21302188, 81072576, 91027033) and Chinese Academy of Sciences (Nos. KJCX2-EW-N06-01 and XDA09030307) for financial support. |
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| 摘 要： | A novel method for achieving a copper(II)-catalyzed domino reaction for the construction of 2-aryl quinazolinones,without the addition of any ligand and additive,has been developed.The domino reaction achieved N-(a-substituted)benzylation,benzylic C–H amidation,and C–C(or C–H) bond cleavage.
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| 收稿时间： | 2014-10-10 |
| 修稿时间： | 2014-12-01 |
Cu(II)-catalyzed domino reaction of 2-halobenzamide and arylmethanamine to construct 2-aryl quinazolinone |
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| Ben-Quan Hu,Li-Xia Wang,Jun-Feng Xiang,Luo Yang,Ya-Lin Tang. Cu(II)-catalyzed domino reaction of 2-halobenzamide and arylmethanamine to construct 2-aryl quinazolinone[J]. Chinese Chemical Letters, 2015, 26(3): 369-372. DOI: 10.1016/j.cclet.2014.12.006 |
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| Authors: | Ben-Quan Hu Li-Xia Wang Jun-Feng Xiang Luo Yang Ya-Lin Tang |
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| Affiliation: | a State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing 100190, China;b Key Laboratory for Environmentally Friendly Chemistry and Application, Department of Chemistry, Xiangtan University, Hunan 411105, China |
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| Abstract: | A novel method for achieving a copper(II)-catalyzed domino reaction for the construction of 2-aryl quinazolinones, without the addition of any ligand and additive, has been developed. The domino reaction achieved N-(α-substituted)benzylation, benzylic C-H amidation, and C-C (or C-H) bond cleavage. |
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| Keywords: | Copper (II)-catalysis Domino reaction 2-Aryl quinazolinones C-C Bond cleavage C-H bond cleavage |
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