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Synthesis of nucleoside tetraphosphates and dinucleoside pentaphosphates from nucleoside phosphoropiperidates via the activation of P(V)-N bond |
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| Authors: | Qi Sun Jian Sun Shan-Shan Gong Cheng-Jun Wang Xing-Cong Wang |
| Affiliation: | Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, China |
| Abstract: | A novel and efficient method for the preparation of nucleoside 50-tetraphosphates has been developed by coupling nucleoside 5''-phosphoropiperidates with triphosphate reagent in the presence of 4, 5-dicyanoimidazole (DCI) activator. Further coupling of the nucleoside 5''-tetraphosphates with nucleoside 50-phosphoropiperidates via the P(V)-N activation strategy provided a reliable synthetic method for both symmetrical and asymmetrical dinucleoside pentaphosphates. |
| Keywords: | 4,5-Dicyanoimidazole Phosphoropiperidate Nucleoside tetraphosphate Dinucleoside pentaphosphate P(V)-N activation |
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