| Folate binding protein—Outlook for drug delivery applications |
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| 引用本文： | Rachel L. Merzel,Jun-Jie Chen,E. Neil G. Marsh,Mark M. Banaszak Holl. Folate binding protein—Outlook for drug delivery applications[J]. 中国化学快报, 2015, 26(4): 426-430. DOI: 10.1016/j.cclet.2014.12.015 |
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| 作者姓名： | Rachel L. Merzel Jun-Jie Chen E. Neil G. Marsh Mark M. Banaszak Holl |
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| 作者单位： | Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA |
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| 摘 要： |
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| 收稿时间： | 2014-11-18 |
| 修稿时间： | 2014-12-08 |
Folate binding protein-Outlook for drug delivery applications |
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| Rachel L. Merzel,Jun-Jie Chen,E. Neil G. Marsh,Mark M. Banaszak Holl. Folate binding protein-Outlook for drug delivery applications[J]. Chinese Chemical Letters, 2015, 26(4): 426-430. DOI: 10.1016/j.cclet.2014.12.015 |
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| Authors: | Rachel L. Merzel Jun-Jie Chen E. Neil G. Marsh Mark M. Banaszak Holl |
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| Affiliation: | Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA |
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| Abstract: | Serum proteins represent an important class of drug and imaging agent delivery vectors. In this minireview, key advantages of using serum proteins are discussed, followed by the particular advantages and challenges associated with employing soluble folate binding protein. In particular, approaches employing drugs that target folate metabolism are reviewed. Additionally, the slow-onset, tightbinding interaction of folate with folate binding protein and the relationship to a natural oligomerization mechanism is discussed. These unique aspects of folate binding protein suggest interesting applications for the protein as a vector for further drug and imaging agent development. |
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| Keywords: | Folate binding protein Serum protein Drug delivery Folate conjugate Folic acid |
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