Analysis of chloramphenicol in honey by on-line pretreatment liquid chromatography-tandem mass spectrometry |
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Authors: | Shin-ichi Kawano Hong-Yuan Hao Yuki Hashi Jin-Ming Lin |
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Affiliation: | a Department of Chemistry, Beijing Key Laboratory of Microanalytical Methods and Instrumentation, Tsinghua University, Beijing 100084, China;b Shimadzu Global COE for Application & Technical Development, Shimadzu (China) Co., Ltd., Shanghai 200052, China |
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Abstract: | Chloramphenicol is an antibiotic and one of the potential contaminants in honey. Solid-phase extraction is the key pretreatment procedure for analysis of chloramphenicol in honey. In this work, an on-line pretreatment liquid chromatography-tandem mass spectrometer system for sensitive, reliable and higher throughput analysis was developed. With the methylcellulose-immobilized reversed-phase column, sugars in a honey sample were efficiently removed in 1 min. As a result, the limit of quantitation of chloramphenicol was 20 pg/mL (0.2 mg/kg honey). |
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Keywords: | On-line pretreatment Liquid chromatography-mass spectrometry Chloramphenicol Honey |
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