Synthesis and spectroscopic characterization of novel 2-amino-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidine and pyrimido[1,2-a]pyrimidine derivatives |
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Authors: | Mohamed SA El-Gaby Jehan A Micky Nadia M Saleh Yousry A Ammar Heba SA Mohamed |
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Institution: | a Chemistry Department, Faculty of Science, Al-Azhar University at Assiut, 71524 Assiut, Egypt;
b Chemistry Department, Faculty of Science (Girl's), Al-Azhar University, Nasr City, Cairo, Egypt;
c Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt;
d Photochemistry Department, National Research Center, El-Dokki, Giza, Egypt |
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Abstract: | 2-Aminocyclopentad]pyrimidines 3a-c were achieved via a one-pot, three-component reactions of cyclopentanone 1, aromatic aldehyde and guanidine hydrochloride (1:2:1 molar ratio). Also, cyclization of 2,5-bis-(arylmethylidene)cyclopentanones 2 with guanidine hydrochloride (1:1 molar ratio) in methanol in the presence of sodiummethoxide afforded cyclopenta-d]pyrimidines 3. Compound 3a has been shown to be a useful building block for the synthesis of some novel pyrimido1,2-a]pyrimidines 5, 7 and 12. The structures of the newly synthesized compounds were confirmed on the basis of analytical and spectral data. |
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Keywords: | Multicomponent reaction Cyclopenta[d]pyrimidine Pyrimido[1 2-a]pyrimidine Cyclopentanone |
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