| C_2-symmetric BINOL-squaramide as efficient organocatalyst for the enantioselective α-amination of 1,3-dicarbonyl compounds with dialkyl azodicarboxylates |
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| 引用本文： | Shi Tang,Zhi-yong Wang,Bin Liu,Chun-E. Dong. C_2-symmetric BINOL-squaramide as efficient organocatalyst for the enantioselective α-amination of 1,3-dicarbonyl compounds with dialkyl azodicarboxylates[J]. 中国化学快报, 2015, 26(6): 744-748. DOI: 10.1016/j.cclet.2015.03.033 |
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| 作者姓名： | Shi Tang Zhi-yong Wang Bin Liu Chun-E. Dong |
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| 作者单位： | State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China |
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| 基金项目： | We are grateful to the Fundamental Research Funds for the Central Universities (No. 2042014kf0248) for support of this research. |
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| 摘 要： |
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| 收稿时间： | 2014-12-17 |
| 修稿时间： | 2015-03-05 |
C2-symmetric BINOL-squaramide as efficient organocatalyst for the enantioselective α-amination of 1,3-dicarbonyl compounds with dialkyl azodicarboxylates |
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| Shi Tang,Zhi-yong Wang,Bin Liu,Chun-E. Dong. C2-symmetric BINOL-squaramide as efficient organocatalyst for the enantioselective α-amination of 1,3-dicarbonyl compounds with dialkyl azodicarboxylates[J]. Chinese Chemical Letters, 2015, 26(6): 744-748. DOI: 10.1016/j.cclet.2015.03.033 |
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| Authors: | Shi Tang Zhi-yong Wang Bin Liu Chun-E. Dong |
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| Affiliation: | State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China |
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| Abstract: | The asymmetric α-amination of 1,3-dicarbonyl compounds with dialkyl azodicarboxylates has been achieved by C2-symmetric BINOL-squaramide bearing multiple hydrogen bond donors to provide the desired products in excellent yields and enantioselectivities (up to 99% yield and 98% ee). |
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| Keywords: | Asymmetric amination 1,3-Dicarbonyl compound Dialkyl azodicarboxylates |
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