Synthesis and deprotonation of 2-(pyridyl)phenols and 2-(pyridyl)anilines |
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Authors: | Rebstock Anne-Sophie Mongin Florence Trécourt François Quéguiner Guy |
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Institution: | Laboratoire de Chimie Organique Fine et Hétérocyclique, IRCOF, UMR 6014, Place E. Blondel, BP 08, 76131 Mont-Saint-Aignan, France. |
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Abstract: | 2-(2- and 3-Pyridyl)anilines (1, 2), 2,2-dimethyl-N-2-(2- and 3-pyridyl)phenyl]propanamides (3, 4), and 2-, 3- and 4-(2-methoxyphenyl)pyridines (7-9) are readily synthesized using cross-coupling reactions. Whereas the amines 1, 2 undergo side reactions, the corresponding amides 3, 4 are deprotonated with lithium 2,2,6,6-tetramethylpiperidide (LTMP): the compound 3 at C6' under in situ quenching, and the compound 4 at C4'. When the ether 7 is subjected to the same reagent, lithiation occurs at C6'. |
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