Photocaged prodrug under NIR light-triggering with dual-channel fluorescence: <Emphasis Type="Italic">in vivo</Emphasis> real-time tracking for precise drug delivery |
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Authors: | Zhiqian Guo Yaguang Ma Yajing Liu Chenxu Yan Ping Shi He Tian Wei-Hong Zhu |
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Institution: | 1.Key Laboratory for Advanced Materials and Institute of Fine Chemicals, Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai,China;2.State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai,China |
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Abstract: | Light-triggered drug delivery system is an effective strategy for precise diagnosis and therapy in cancer treatment. However, it suffers from difficultly balancing the dosimetry of drug with light dose and a lack of in vivo models for validating their clinical benefits. Here we report an unprecedented near-infrared (NIR) light photocaged cyanine-based prodrug Cy-CPT-Biotin with dual-channel fluorescence mode, enabling NIR light to precisely regulate where, when and how the intact and active prodrugs are delivered. The synergy of photochemical reaction and modulation in π-conjugated polyene backbone of cyanine can fully perform distinct dual-channel fluorescence changes in a NIR light-mediated manner. The prodrug has striking characteristics of excellent tumor-targeting ability, real-time monitoring of the in vivo behaviors by dual-channel mode and NIR-light triggering, especially for achieving fine regulation and on-demand drug release in the precise dosimetry of drug with light dose in living animals. This optical orthogonality strategy that conjuncts with NIR light-triggered and dual-channel fluorescence in vivo imaging provides a powerful tool for in vivo real-time tracking and finely tuning the prodrug release for precise drug delivery. |
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