CuI/L-proline-catalyzed coupling reactions of aryl halides with activated methylene compounds |
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Authors: | Xie Xiaoan Cai Guorong Ma Dawei |
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Affiliation: | Department of Chemistry, Fudan University, Shanghai 200433, China. |
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Abstract: | [reaction: see text] The arylation of ethyl acetoacetate, ethyl benzoyl acetate, and diethyl malonate under the catalysis of CuI/L-proline in DMSO proceeds smoothly at 40-50 degrees C in the presence of Cs2CO3 to provide the 2-aryl-1,3-dicarbonyl compounds in good yields. Both aryl iodides and aryl bromides are compatible with these reaction conditions. |
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