A new griseofulvin derivative from the mangrove endophytic fungus <Emphasis Type="Italic">Sporothrix</Emphasis> SP. |
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Authors: | Lu Wen Zhiyong Guo Qing Li Dezhi Zhang Zhigang She L L P Vrijmoed |
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Institution: | (1) College of Pharmacy, Guangdong Pharmaceutical University, 510006 Guangzhou, China;(2) College of Chemistry and Life Science, China Three Gorges University, 443002 Yichang, China;(3) School of Chemical and Chemical Engineering, Sun Yat-Sen (Zhongshan) University, 510275 Guangzhou, China;(4) Department of Biology and Chemistry, City University of Hong Kong, Hong Kong, China |
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Abstract: | A new griseofulvin derivative, 7-chloro-2',5,6-trimethoxy-6'-methylspiro(benzofuran-2(3H),1'-(2) cyclohexene)3,4'-dione (1),
together with the known 2-acetyl-7-methoxybenzofuran (2), was isolated from the marine-derived mangrove endophytic fungus
Sporothrix sp. (No. 4335). The structure of new compound 1 was elucidated by analysis of spectroscopic data. |
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