Synthesis of 17α-amino-5α-androst-2-ene from epiandrosterone |
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| Authors: | M I Merlani L Sh Amiranashvili E P Kemertelidze K Papadopulos E Yannakopulu |
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| Institution: | (1) I. G. Kutatelazde Institute of Pharmaceutical Chemistry, Academy of Sciences of Georgia, Tbilisi, 0159;(2) Institute of Physical Chemistry, National Scientific Research Center Demokritos, Athens, Greece |
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| Abstract: | 17α-Amino-5ga-androst-2-ene was synthesized from epiandrosterone via formation of the tosylate followed by nucleophilic substitution
by azide and reduction with LiAlH4. The structures of the products were proved by NMR and IR spectroscopy and mass spectrometry.
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Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 257–258, May–June, 2006. |
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| Keywords: | aminosteroids synthesis |
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