Highly-sensitive ion selective electrode based on molecularly imprinted polymer particles for determination of tetracycline in aqueous samples |
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Authors: | Panpan Gai Zhiyong Guo Fei Yang Jing Duan Tingting Hao Sui Wang |
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Institution: | 1.Faculty of Materials Science and Chemical Engineering, the State Key Laboratory Base of Novel Functional Materials and Preparation Science,Ningbo University,Ningbo,China |
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Abstract: | In this work, a highly-sensitive polymeric membrane ion selective electrode for determination of tetracycline was constructed
by using molecularly imprinted polymer (MIP) particles as quasi-ionophore. The water-compatible MIP particles targeting tetracycline
were synthesized with tetracycline as a template molecule, methacrylic acid as a functional monomer, ethylene glycol dimethacrylate
as a cross-linker, 2,2′-azobisisobutyronitrile as an initiator and lanthanum ion as a mediator. Benefited from the distinctive
performance of the quasi-ionophore and the optimized composition of the membrane and the inner filling solution, the lower
detection limit of the electrode was decreased to about 1 × 10−8 mol/l. It exhibited a good electrode slope 59.8 mV/decade near the theoretical Nernstian one, with a wide linear working
range from 2.0 × 10−8 to 1.0 × 10−3 mol/l. Due to the specific recognition of tetracycline by the MIP particles, the selectivity coefficients for routine interferences
were less than 10−4. The fabricated electrode should be used in pH 2–4, response time of which was less than 200 s when the concentration of
tetracycline was higher than 1.0 × 10−6 mol/l and no more than 30 min at the concentration of 1.0 × 10−8 mol/l. Finally, the proposed highly-sensitive ion selective electrode has been successfully applied to the determination
of tetracycline in aqueous samples. |
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