Intra‐ and Intermolecular Nickel‐Catalyzed Reductive Cross‐Electrophile Coupling Reactions of Benzylic Esters with Aryl Halides |
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| Authors: | Mikhail O. Konev Luke E. Hanna Prof. Dr. Elizabeth R. Jarvo |
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| Affiliation: | Department of Chemistry, University of California, Irvine, Irvine, CA, USA |
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| Abstract: | Nickel‐catalyzed cross‐electrophile coupling reactions of benzylic esters and aryl halides have been developed. Both inter‐ and intramolecular variants proceed under mild reaction conditions. A range of heterocycles and functional groups are tolerated under the reaction conditions. Additionally, the first example of a stereospecific cross‐electrophile coupling of a secondary benzylic ester is described. |
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| Keywords: | cross-coupling cyclization heterocycles nickel zinc |
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