Chiral Nanoparticles/Lewis Acids as Cooperative Catalysts for Asymmetric 1,4‐Addition of Arylboronic Acids to α,β‐Unsaturated Amides |
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Authors: | Dr. Tomohiro Yasukawa Yuuki Saito Dr. Hiroyuki Miyamura Prof. Dr. Shū Kobayashi |
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Affiliation: | Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan |
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Abstract: | Cooperative catalysts consisting of chiral Rh/Ag nanoparticles and Sc(OTf)3 have been developed that catalyze asymmetric 1,4‐addition reactions of arylboronic acids with α,β‐unsaturated amides efficiently. The reaction has been considered one of the most challenging reactions because of the low reactivity of the amide substrates. The new catalysts provide the desired products with outstanding enantioselectivities (>98 % ee) in the presence of low loadings (<0.5 mol %) of the catalyst. |
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Keywords: | cooperative effects heterogeneous catalysis Lewis acid nanoparticles Rh catalysis |
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