Iron‐catalyzed Cross‐Coupling of Propargyl Carboxylates and Grignard Reagents: Synthesis of Substituted Allenes |
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| Authors: | Dr. Simon N. Kessler Prof. Dr. Jan‐E. Bäckvall |
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| Affiliation: | Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Stockholm, Sweden |
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| Abstract: | Presented herein is a mild, facile, and efficient iron‐catalyzed synthesis of substituted allenes from propargyl carboxylates and Grignard reagents. Only 1–5 mol % of the inexpensive and environmentally benign [Fe(acac)3] at ?20 °C was sufficient to afford a broad range of substituted allenes in excellent yields. The method tolerates a variety of functional groups. |
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| Keywords: | allenes chirality cross-coupling Grignard reagents iron |
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