Cationic Cobalt(III) Catalyzed Indole Synthesis: The Regioselective Intermolecular Cyclization of N‐Nitrosoanilines and Alkynes |
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Authors: | Yujie Liang Dr Ning Jiao |
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Institution: | 1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China;2. http://sklnbd.bjmu.edu.cn/nj/;3. State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai, China |
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Abstract: | The unique regioselectivity and reactivity of cobalt(III) in the direct cyclization of N‐nitrosoanilines with alkynes for the expedient synthesis of N‐substituted indoles is demonstrated. In the presence of a cobalt(III) catalyst, high regioselectivity was observed when using unsymmetrical meta‐substituted N‐nitrosoanilines. Moreover, internal alkynes bearing electron‐deficient groups, which are almost unreactive in the Cp*RhIII]‐catalyzed system, display good reactivity in this transformation. |
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Keywords: | C− H activation cobalt indoles reaction mechanisms regioselectivity |
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