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Total Synthesis of Cryptocaryol A by Enantioselective Iridium‐Catalyzed Alcohol C−H Allylation |
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| Authors: | Dr. Felix Perez Andrew R. Waldeck Prof. Michael J. Krische |
| Affiliation: | University of Texas at Austin, Department of Chemistry, Austin, TX, USA |
| Abstract: | The polyketide natural product cryptocaryol A is prepared in 8 steps via iridium catalyzed enantioselective diol double C?H allylation, which directly generates an acetate‐based triketide stereodiad. In 4 previously reported total syntheses, 17–28 steps were required. |
| Keywords: | enantioselective synthesis iridium polyketide total synthesis transfer hydrogenation |