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Generalizing the Concept of Specific Compound Formulation Additives towards Non‐Fluorescent Drugs: A Solubilization Study on Potential Anti‐Alzheimer‐Active Small‐Molecule Compounds |
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| Authors: | Carmen Lawatscheck Dr. Marcus Pickhardt Sebastian Wieczorek Dr. Andrea Grafmüller Prof. Dr. Eckhard Mandelkow Prof. Dr. Hans G. Börner |
| Affiliation: | 1. Humboldt-Universit?t zu Berlin, Department of Chemistry, Berlin, Germany;2. German Center for Neurodegenerative Diseases (DZNE), CAESAR Research Center, Bonn, Germany;3. Max Planck Institute of Colloids and Interfaces, Department of Theory and Biosystems, Potsdam, Germany;4. MPI for Metabolism Research, Hamburg Outstation, c/o DESY, Hamburg, Germany |
| Abstract: | Tailor‐made compound formulation additives enable the testing of potential drugs with undesirable pharmacological profiles. A combinatorial approach using Raman microscopy as the readout method is presented to select peptide sequences from large one‐bead‐one‐compound libraries. The resulting peptide–PEG conjugates solubilize potential prophylactic and therapeutic anti‐Alzheimer compounds and can be used as specific additives not only for fluorescent but also for non‐fluorescent compounds. |
| Keywords: | Alzheimer's disease bioconjugates combinatorial screening precision polymers Tau protein |