Palladium(0)‐Catalyzed Intermolecular Carbocyclization of (1,n)‐Diynes and Bromophenols: An Efficient Route to Tricyclic Scaffolds |
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Authors: | Lu Bai Yini Yuan Prof. Dr. Jingjing Liu Jiaoyu Wu Lingbo Han Dr. Hui Wang Prof. Dr. Yaoyu Wang Prof. Dr. Xinjun Luan |
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Affiliation: | 1. Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an, China;2. State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin, China |
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Abstract: | A novel palladium(0)‐catalyzed dearomative cyclization reaction of bromophenols with (1,n)‐diynes has been developed for building two new types of tricyclic architectures containing a quaternary carbon center. This method employs inexpensive bromophenols, and easily accessible tethered diynes. It exhibits a broad substrate scope and tolerates various functional groups. Preliminary results with commercially available chiral ligands indicate that enantioselective variants are feasible for both cyclization processes. |
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Keywords: | alkynes arenes cyclizations dearomatization palladium |
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